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. 2019 Jan 9;9:3094. doi: 10.3389/fimmu.2018.03094

Figure 3.

Figure 3

CD27 MFI ratio according to the study group. A ratio based on CD27 MFI was calculated after specific stimulation as suggested by Portevin et al. (16). This ratio is based on the MFI of CD27 in CD4+ T-cells over MFI of CD27 in IFN-γ+CD4+ T-cells. (A) CD27 MFI ratio after PPD or (B) ESAT-6/CFP-10 stimulation in patients with active TB and LTBI individuals. Horizontal lines represent medians. Differences between conditions were calculated using the two-tailed Mann-Whitney U-test. ****p < 0.0001. (C,D) Correlation of the percentage of CD27− marker within IFN-γ+CD4+ specific T-cells with the CD27 MFI ratio after PPD or ESAT-6/CFP-10 stimulation. Correlation was calculated using the two-tailed non-parametric Spearman test. aTB, active TB; LTBI, latent tuberculosis infection.