Table 1.
Demographic and clinical characteristics of the participants regarding the study group.
| VARIABLES | Active TB | LTBI |
|---|---|---|
| Participants, n | 22 | 26 |
| Mean age, years ± SD | 38.68 ± 15.35 | 47.65 ± 15.77 |
| Male gender, n(%) | 18 (81.8) | 12 (46.2) |
| POSITIVE PCR, n(%) | ||
| Positive | 10 (45.4) | – |
| Negative | 4 (18.2) | – |
| Unknown | 8 (36.4) | – |
| TYPE of TB | ||
| Pulmonary | 18 (81.8) | – |
| Extrapulmonarya | 4 (18.2) | – |
| ANTI-TB TREATMENT, n(%) | ||
| Before starting treatment | 3 (13.6) | – |
| After starting treatment (< 1month) | 19 (86.4) | – |
| Not prescribed | – | 26 (100) |
| Mean time of anti-TB treatment, days ± SD | 15.14 ± 9.77 | – |
| CHEMOPROPHYLAXIS, n(%) | ||
| Before starting treatment | – | 2 (7.7) |
| After starting treatment (< 1month) | – | 24 (92.3) |
| Not prescribed | 22 (100) | – |
| Mean time of chemoprophylaxis, days ± SD | – | 18.6 ± 8.06 |
| PPD CYTOMETRY RESPONDERS, n(%)b | ||
| IFNγ+CD4+ T cells | 22 (100) | 26 (100) |
| TNF-α+CD4+ T-cells | 22 (100) | 26 (100) |
| TNF-α+IFN-γ +CD4+ T-cells | 22 (100) | 26 (100) |
| IFNγ+and/orTNF-α+CD4+ T-cells | 22 (100) | 26 (100) |
| ESAT-6/CFP-10 CYTOMETRY RESPONDERS, n(%)b | ||
| IFNγ+CD4+ T cells | 21 (95.5) | 21 (80.8) |
| TNF-α+CD4+ T-cells | 22 (100) | 25 (96.2) |
| TNF-α+IFN- γ +CD4+ T-cells | 21 (95.5) | 21 (80.8) |
| IFNγ+and/orTNF-α+CD4+ T-cells | 22 (100) | 25 (96.2) |
a
Pleural TB (n = 2), ganglionar TB (n = 1), and pericardical TB (n = 1).
b
Number of individuals with a positive CD4+ T-cell response to the specified antigen. The frequency of the response to any cytokine after specific stimulation was defined as positive when it was twice the amount when compared to its negative control (unstimulated sample).
TB, tuberculosis; LTBI, latent tuberculosis infection; SD, standard deviation; PPD, purified protein derivative.