Table 2.
ROC curve analysis of the different approaches.
| PHENOTYPE | AUC (95% CI) | |
|---|---|---|
| PPD | ESAT-6/CFP-10 | |
| CD27− | ||
| IFNγ+CD4+ | 0.85 (0.72–0.97) | 0.90 (0.79–1.01) |
| TNF-α+CD4+ | 0.85 (0.74–0.97) | 0.86 (0.75–0.97) |
| TNF-α+IFN-γ+CD4+ | 0.88 (0.77–098) | 0.92 (0.84–1.01) |
| IFNγ+and/orTNF-α+CD4+ | 0.82 (0.69–0.95) | 0.87 (0.76–0.98) |
| CCR4+ | ||
| IFNγ+CD4+ | 0.73 (0.59–0.87) | 0.60 (0.43–0.78) |
| TNF-α+CD4+ | 0.70 (0.55–0.85) | 0.50 (0.33–0.67) |
| TNF-α+IFN-γ+CD4+ | 0.77 (0.64–0.91) | 0.65 (0.49–0.83) |
| IFNγ+and/orTNF-α+CD4+ | 0.72 (0.58–0.87) | 0.59 (0.43–0.75) |
| CD27−CCR4+ | ||
| IFNγ+CD4+ | 0.91 (0.83–0.99) | 0.86 (0.73–0.98) |
| TNF-α+CD4+ | 0.90 (0.82–0.99) | 0.84 (0.71–0.96) |
| TNF-α+IFN-γ+CD4+ | 0.90 (0.81–0.99) | 0.89 (0.77–0.99) |
| IFNγ+and/orTNF-α+CD4+ | 0.88 (0.78–0.97) | 0.84 (0.71–0.96) |
| MFI CD27 | ||
| IFNγ+CD4+ | 0.84 (0.71–0.97) | 0.90 (0.79–1.01) |
| TNF-α+CD4+ | 0.84 (0.71–0.97) | 0.87 (0.76–0.97) |
| TNF-α+IFN-γ+CD4+ | 0.84 (0.71–0.97) | 0.91 (0.82–1.01) |
| IFNγ+and/orTNF-α+CD4+ | 0.84 (0.71–0.97) | 0.88 (0.77–0.99) |
AUC, area under the curve; CI, confidence interval; PPD, purified protein derivative.