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. 2019 Jan 9;9:791. doi: 10.3389/fendo.2018.00791

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Copyright © 2019 Moin, Montemurro, Zeng, Cory, Nguyen, Kulkarni, Fritsch, Meier, Dhawan, Rizza, Atkinson and Butler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of number of CPHN cells expressing transcription factors NKX6.1 and NKX2.2 in different compartments of fetal and infant/child pancreas. CPHN cells that express either NKX6.1 or NKX2.2 showed variability in their numbers among different compartments of the pancreas sections of both fetal and infant cases. The number of CPHN cells located within the islets that expressed either NKX6.1 (A) or NKX2.2 (D) was similar in fetal and infant/child cases but NKX6.1⁺ and NKX2.2⁺ CPHN cells found as clusters (B,E) or single cells (C,F) were significantly higher in fetal cases compared to infant/child cases. ^**p < 0.01, n = 7 for fetal cases and n = 10 for infant/child cases.