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. 2019 Mar;14(3):373–386. doi: 10.4103/1673-5374.245462

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Copyright: © Neural Regeneration Research

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EBV viral structure and genome.

(A) EBV is illustrated in a 2D model. The glycoproteins are embedded on the outer surface of viral envelope. Inside the envelope, the matrix is named tegument. The packaged viral DNA is enclosed within the nucleocapsid. (B) EBV genome shown as a circular, double-stranded DNA. The arrowheads correspond to the direction of latent gene transcription. The outer large arrow represent the transcription of EBNA-2 and EBNA-3 initiated from the Cp or Wp promoter. The inner smaller arrow indicate the transcription of EBNA-1 from the Qp promoter. EBV: Epstein-Barr virus; LMP: latent membrane protein; EBNA: EBV nuclear antigen; VCA: viral capsid antigen; EA: early antigen; Kb: thousand base pair.