. Author manuscript; available in PMC: 2020 Jan 1.

Published in final edited form as: Skin Res Technol. 2018 Jul 21;25(1):3–11. doi: 10.1111/srt.12617

Table 1.

Partial list of lipid mediators directly quantified in subjects with and without cutaneous disease. Unless otherwise specified, all lipid mediators were quantified in affected human skin. With the exception of the sphingolipids, concentrations of all lipid mediators increased in individuals with the disease compared to control.

Disease	Associated Cutaneous Lipid Mediators
Atopic Dermatitis	PGE2 (26), 12-HETE (26), 15-HETE (26), LTB4 (26, 27), LTC4 (27), LTE4 (27), PEA (28) ^†, OEA (28) ^†, AEA (28) ^†, 2-AG (28) ^†, total Ceramides (29), Sphingosine-1-Phosphate (30) ^†, 18:0 Sphingosine (31)
Contact Dermatitis	2-AG (32) ^‡, 2-LG (32) ^‡, 2-PG (32) ^‡, 2-VG (32) ^‡, PEA (33) ^‡, AEA (34) ^‡
Irritant Dermatitis	TXB2 (35), 12-HETE (35), SEA (35), OEA (35), LEA (35), PEA (35)
Psoriasis	PGE2 (36), PGF2a (36), 12-HETE (36), total Ceramides (37)
Wound Healing	PGE2 (38), PGD2 (38), AEA (39)
Sunburn	PGE1 (40), PGE2 (40), PGE3 (40), PGF2a (40), 8-HETE (40), 11-HETE (40), 12-HETE (40), 15-HETE (40), 13-HODE (40), LTB4 (41) ^§, AEA (42) ^‡, LEA (42) ^‡, PEA (42) ^‡, SEA (42) ^‡, OEA (42) ^‡, VEA (42) ^‡, total Ceramides (43) ^‡

^†

Data generated from canine models

^‡

Data generated from murine models

^§

Data generated from cultured human fibroblast models