Table 4.
PBC Monocyte Derived Macrophage (MDM) Receptor and Serum Biochemical Levels Correlate with Phagocytose of Apoptotic Cells.
| % Phagocytosis | CD11b | CD16 | CD14 | T bili | Chol ratio | |
|---|---|---|---|---|---|---|
| HI-FBS | r value | −0.541 | −0.519 | 0.000 | −0.509 | 0.102 |
| norm-op | p value | 0.035 | 0.042 | 1.000 | 0.046 | 0.376 |
| Auto | r value | −0.512 | −0.547 | −0.332 | −0.306 | 0.109 |
| norm-op | p value | 0.044 | 0.033 | 0.146 | 0.167 | 0.668 |
| HI-FBS | r value | 0.318 | −0.133 | −0.547 | −0.224 | 0.571 |
| non-op | p value | 0.157 | 0.340 | 0.033 | 0.242 | 0.026 |
| HI-FBS | r value | −0.014 | −0.297 | −0.578 | −0.250 | 0.472 |
| auto-op | p value | 0.883 | 0.174 | 0.025 | 0.217 | 0.061 |
Spearman analysis was used to assess correlations between MDM phagocytosis and MDM receptor expression levels as well as serum biochemical values. An r value ≥/0.500/ was considered a strong correlation and statistically significant if the p value was ≤ 0.050. A (−) sign indicates an inverse correlation. % phagocytosis refers to the percentage of CD14+ MDM that phagocytosed an apoptotic cell under the indicated conditions. Cells were cultured in media supplemented with HI-FBS or autologous serum (Auto) and then exposed to apoptotic cells opsonized with normal human serum (norm-op), autologous serum (auto-op), or HI-FBS (non-op). T bill is total serum bilirubin and ratio is serum total cholesterol divided by HDL cholesterol levels.