Fig. 2.

Mast cell deficiency decreases chemokine CCL2 level in the brain lysates of MC-KO mice after MPTP administration. CCL2 level was measured by ELISA in the brain lysates of MPTP administered Wt. mice, GMF-KO mice, MC-KO mice and untreated control mice (n=3/group). Our results show that CCL2 level increased in Wt. mice brain administered with MPTP as compared with control mice. Both GMF-KO mice and MC-KO mice show reduced levels CCL2 as compared with Wt. mice with MPTP administration. *p<0.05, Vs. Wt. Control, ANOVA and Tukey-Kramer post hoc test.