Table 1.
Baseline demographics and disease for patients with or without NEs on study
| Original evaluation cohort (N = 189) | ||
|---|---|---|
| Characteristic | Patients with NEs (n = 98) | Patients without NEs (n = 91) |
| Median (range) age, year | 41 (19–79) | 34 (18–72) |
| Age < 65 year, n (%) | 80 (82) | 84 (92) |
| Age ≥ 65 year, n (%) | 18 (18) | 7 (8) |
| Sex, n (%) | ||
| Men | 59 (60) | 60 (66) |
| Women | 39 (40) | 31 (34) |
| Race or ethnic group, n (%) | ||
| White | 71 (72) | 74 (81) |
| Othera | 16 (16) | 8 (9) |
| Missing | 11 (11) | 9 (10) |
| Primary refractory, n (%) | ||
| No | 91 (93) | 82 (90) |
| Yesb | 7 (7) | 9 (10) |
| Prior allogeneic HSCT, n (%) | ||
| 0 | 63 (64) | 62 (68) |
| 1 | 30 (31) | 24 (26) |
| 2 or 3 | 5 (5) | 5 (5) |
| Prior salvage treatment, n (%) | ||
| 0 | 21 (21) | 17 (19) |
| 1 | 40 (41) | 37 (41) |
| 2 | 14 (14) | 28 (31) |
| > 2 | 23 (23) | 9 (10) |
| Bone marrow blast count per central read, n (%) | ||
| < 50% | 35 (36) | 24 (26) |
| ≥ 50% | 63 (64) | 67 (74) |
| Prephase dexamethasone administration, n (%) | ||
| No | 29 (30) | 30 (33) |
| Yes | 69 (70) | 61 (67) |
| Prior history of NEs, n (%) | ||
| No | 55 (56) | 68 (75) |
| Yes | 43 (44) | 23 (25) |
| Cranial radiation for CNS ALL, n (%) | 15 (15) | 14 (15) |
NE neurologic event, HSCT hematopoietic stem cell transplantation
aBlack (n = 7), Asian (n = 6), American Indian or Alaska Native (n = 1), Native Hawaiian or other Pacific Islander (n = 1), and other (n = 9). Race was not recorded for patients from France and one additional patient for privacy reasons
bPrior salvage therapies: none (n = 4), one (n = 7), two (n = 3), three or more (n = 2)