Table 2.
Adverse events regardless of causality occurring in ≥ 10% of patients
| Adverse event | All grades, n (%) | Grade 3/4, n (%) |
|---|---|---|
| Hematologic toxicities | ||
| Lymphopenia | 48 (100) | 46 (96) |
| Leukopenia | 35 (73) | 20 (42) |
| Neutropenia | 27 (56) | 17 (35) |
| Thrombocytopenia | 23 (48) | 12 (25) |
| Anemia | 23 (48) | 11 (23) |
| Febrile neutropenia | 6 (13) | 6 (13) |
| Non-hematologic toxicities | ||
| Constipation | 13 (27) | 1 (2) |
| Nasopharyngitis | 13 (27) | 0 (0) |
| Hypoalbuminemia | 12 (25) | 2 (4) |
| Edema | 12 (25) | 0 (0) |
| Pyrexia | 11 (23) | 1 (2) |
| Stomatitis | 11 (23) | 1 (2) |
| Headache | 11 (23) | 0 (0) |
| Insomnia | 10 (21) | 0 (0) |
| Alanine aminotransferase increased | 10 (21) | 1 (2) |
| Nausea | 9 (19) | 1 (2) |
| Decreased appetite | 9 (19) | 4 (8) |
| Malaise | 8 (17) | 0 (0) |
| Aspartate aminotransferase increased | 8 (17) | 0 (0) |
| Rash | 8 (17) | 0 (0) |
| Abnormal hepatic function | 7 (15) | 3 (6) |
| Herpes zoster | 7 (15) | 1 (2) |
| Pruritus | 7 (15) | 0 (0) |
| Protein in urine | 7 (15) | 0 (0) |
| Vomiting | 6 (13) | 0 (0) |
| Cytomegalovirus infection | 5 (10) | 0 (0) |
| Pneumonia | 5 (10) | 4 (8) |
| Hyponatremia | 5 (10) | 4 (8) |
| Decreased weight | 5 (10) | 1 (2) |