Table 2.
Univariate analysis for the risk factors of transplant outcomes in prophylactic DLI recipients
| Variable | Grades II–IV acute GVHD | Grades III–IV acute GVHD | Chronic GVHD | NRM | Relapse | RFS | OS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % (95% CI) | p value | % (95% CI) | p value | % (95% CI) | p value | % (95% CI) | p value | % (95% CI) | p value | % (95% CI) | p value | % (95% CI) | p value | |
| Age | ||||||||||||||
| < 40 years old | 53.6 (26.2–74.8) | 0.505 | 15.3 (2.1–40.1) | 0.312 | 55.2 (16.4–82.2) | 0.942 | 5.6 (0.3–23.3) | 0.018 | 40.6 (17.2–63.0) | 0.214 | 35.9 (8.2–65.7) | 0.409 | 44.3 (12.1–73.1) | 0.213 |
| ≥ 40 years old | 56.8 (19.9–82.1) | 0 | 41.7 (13.5–68.2) | 55.2 (18.6–81.1) | 20.5 (1.9–53.1) | 24.3 (4.1–53.4) | 36.5 (10.2–64.0) | |||||||
| Poor-risk gene mutations | ||||||||||||||
| No | 50.0 (15.7–77.2) | 0.635 | 13.0 (0.4–46.3) | 0.838 | 54.6 (18.2–80.6) | 0.391 | 18.2 (2.3–46.2) | 0.345 | 54.6 (19.9–79.6) | 0.029 | 27.3 (6.5–53.9) | 0.131 | 30.9 (10.6–67.3) | 0.600 |
| Yes | 58.6 (28.7–79.6) | 8.6 (0.4–33.7) | 43.1 (14.0–69.8) | 29.9 (9.9–53.4) | 18.0 (3.9–40.5) | 26.1 (1.8–63.6) | 31.5 (1.8–71.7) | |||||||
| Disease status at transplantation | ||||||||||||||
| CR | 55.9 (30.1–75.5) | 0.889 | 6.8 (0.4–27.5) | 0.526 | 40.8 (16.2–64.4) | 0.346 | 49.1 (11.0–79.5) | 0.194 | 14.3 (3.4–32.6) | 0.005 | 36.7 (8.6–66.3) | 0.130 | 47.5 (16.2–73.7) | 0.371 |
| NR | 54.2 (10.6–84.6) | 17.9 (0.3–60.6) | 48.2 (10.2–79.1) | 11.1 (0.4–41.7) | 74.1 (17.6–95.0) | 14.8 (0.8–46.8) | 23.3 (1.3–61.6) | |||||||
| Donor’s age | ||||||||||||||
| < 40 years old | 60.2 (33.3–79.1) | 0.362 | 6.9 (0.4–28.0) | 0.397 | 52.9 (20.1–77.7) | 0.577 | 43.2 (16.4–67.7) | 0.131 | 24.0 (8.1–44.4) | 0.043 | 32.8 (11.2–56.7) | 0.493 | 35.6 (11.3–61.2) | 0.778 |
| ≥ 40 years old | 43.8 (7.7–76.6) | 17.5 (0.4–57.1) | 14.6 (0.4–50.9) | 0 | 41.7 (7.2–74.7) | 43.8 (10.1–74.2) | 65.6 (15.7–90.9) | |||||||
| Time from diagnosis to transplantation | ||||||||||||||
| < 6 months | 63.3 (29.0–84.5) | 0.352 | 10.7 (0.4–40.0) | 0.922 | 53.8 (11.2–83.9) | 0.827 | 34.2 (11.2–59.1) | 0.531 | 19.4 (4.3–42.4) | 0.145 | 46.4 (20.4–69.0) | 0.415 | 45.0 (19.2–68.0) | 0.492 |
| ≥ 6 months | 49.0 (18.1–74.3) | 10.6 (0.4–39.6) | 48.8 (16.2–75.4) | 32.3 (3.0–69.4) | 49.7 (16.5–76.3) | 18.0 (1.3–50.9) | 20.9 (1.0–58.6) | |||||||
CR, complete remission; NR, non-remission; GVHD, graft-versus-host disease; NRM, non-relapse mortality; OS, overall survival; RFS, relapse-free survival; CI, confidence interval