Fig. 2.

Effects of XE991 on I_SC. a Representative experiment of the apical administration of 100 μM XE991 after the application of amiloride and butyrate. b A summary of the effects of XE991 on I_SC. Bars refer to the cumulative addition of drugs shown in Fig. 2a. c Dose dependency of XE991 for the shift in I_{SC-amil/insen} (n = 5). The solid curve shows the fit of results using the Hill equation (see the "Materials and methods" section). Values are the means ± SE of five experiments