Figure 1.

The cellular balance between transcription fidelity and DNA damage survival. GreA/B and possibly the D. radiodurans protein Gfh,[48,49] increase transcription fidelity at the cost of survival during DNA damage stress. In the absence of GreA/B, transcription fidelity is reduced, but survival after DNA damage is greatly improved. Under DNA damage stress, D. radiodurans is predicted to have a balance between maintaining transcription fidelity and performing DNA repair such that both RNA and DNA fidelity is high (blue dots), while in E. coli, the equilibrium is shifted toward transcription fidelity (green dots).