Table 3. Mean (± s.d) plasma concentrations at 2 hr after PO dosing of ASD FBZ with 0.2, 0.6, 1.5, 6 and 15 mg/kg/day.
PO | ||||||
---|---|---|---|---|---|---|
Doses (mg/kg/day) | Concentrations of FBZ at 2 hours after dosing (ng/ml) | Concentrations at 24h | ||||
Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 5 | |
0.2a | 7.43 ± 5.92 | 9.77 ± 5.46 | 10.2 ± 2.6 | 14.2 ± 10.3 | 14.6 ± 0.7 | 0.559 ± 0.391 |
0.6a | 21.8 ± 16.8 | 22.4 ± 9.6 | 35.8 ± 30.7 | 29.1 ± 21.7 | 38.5 ± 10.9 | 0.547 ± 0.223 |
1.5a | 68.9 ± 24.2 | 79.5 ± 43.0 | 56.8 ± 8.7 | 70.4 ± 35.5 | 84.6 ± 42.1 | 1.38 ± 1.06 |
6b | 268 | 464 | 368 | 424 | 436 | 3.54 |
15b | 1562 | 2084 | 2498 | 974 | 1726 | 39.1 |
a: n = 3
b: n = 2; s.d: standard deviation