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. 2019 Jan 16;13(1):e0006787. doi: 10.1371/journal.pntd.0006787

Table 3. Mean (± s.d) plasma concentrations at 2 hr after PO dosing of ASD FBZ with 0.2, 0.6, 1.5, 6 and 15 mg/kg/day.

PO
Doses (mg/kg/day) Concentrations of FBZ at 2 hours after dosing (ng/ml) Concentrations at 24h
Day 1 Day 2 Day 3 Day 4 Day 5 Day 5
0.2a 7.43 ± 5.92 9.77 ± 5.46 10.2 ± 2.6 14.2 ± 10.3 14.6 ± 0.7 0.559 ± 0.391
0.6a 21.8 ± 16.8 22.4 ± 9.6 35.8 ± 30.7 29.1 ± 21.7 38.5 ± 10.9 0.547 ± 0.223
1.5a 68.9 ± 24.2 79.5 ± 43.0 56.8 ± 8.7 70.4 ± 35.5 84.6 ± 42.1 1.38 ± 1.06
6b 268 464 368 424 436 3.54
15b 1562 2084 2498 974 1726 39.1

a: n = 3

b: n = 2; s.d: standard deviation