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. 2019 Jan 4;17(1):e2006926. doi: 10.1371/journal.pbio.2006926

Fig 7. Model for viral utilization of autophagy pathway components.

Fig 7

Canonical autophagy uses upstream components ULK1/FIP200 complex, VPS34/BECN1 complex, as well as ATG5-mediated lipidation of LC3. PV, DENV, and ZIKV use unique sets of components to induce different membrane structures for viral amplification and spread. ATG5, autophagy-related gene 5; BECN1, beclin-1; DENV, dengue virus; FIP200, PTK2/FAK family interacting protein of 200 kDa; LC3, light-chain 3; PV, poliovirus; ULK1, Unc-like autophagy-activating kinase; ZIKV, Zika virus.