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. 2019 Jan 4;15(1):e1006680. doi: 10.1371/journal.pcbi.1006680

Fig 6. Effect of efficiency of erythropoiesis and RBC lifespan on β-thalassemia phenotypes.

Fig 6

Parameters kInBM and kRBCSpleen were varied and simulated for 365 days. A: effect on transferrin saturation; B: effect on spleen iron content. The efficiency of erythropoiesis is directly proportional to parameter kInBM, while the half-life of RBC is inversely proportional to kRBCSpleen (at 400% the half-life is ¼ of its original value). The contour plots at the base include proposed boundaries between thalassemia major (m), thalassemia intermedia (i) and normal (n) phenotypes in dashed lines (the n-i boundary is somewhat arbitrary, while m-i is dictated by the full saturation of Tf).