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. Author manuscript; available in PMC: 2019 Jan 16.
Published in final edited form as: Vision Res. 2017 Oct 31;139:211–220. doi: 10.1016/j.visres.2017.06.016

Figure 1: Localization of c-Kit+ cells in mouse bone marrow.

Figure 1:

Upper panel: immunofluorescence staining of N-cadherin (red) and c-Kit (green) in demineralized mouse femurs. Some c-Kit+ cells (white arrow) localized to endosteal niche (blue arrow) are defined as long-term repopulating (LTR)-hematopoietic stem cells (HSCs); Lower panel: mouse femurs stained for VE-cadherin (red) and c-Kit (green). c-Kit+ cells (white arrow) located at vascular niche are defined as short-term repopulating (STR)-HSCs. Representative images showing a reduced number of LTR-HSCs and increased STR-HSCs/LTR-HSCs in the STZ-induced diabetic bone marrow. ATM−/− intensified diabetes-mediated defects of LTR- and STR-HSCs imbalance in the bone marrow. Abbreviations: WT, wild type; STZ, streptozotocin; ATM, ataxia telangiectasia mutated.