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. Author manuscript; available in PMC: 2019 Jan 16.
Published in final edited form as: Neuroglia. 2018 Jun 12;1(1):91–105. doi: 10.3390/neuroglia1010008

Figure 1.

Figure 1.

Evolution of α-lysophosphatidylcholine (LPC)-induced demyelinated lesion. Immunofluorescence labeling for myelin basic protein (MBP) and non-phosphorylated neurofilaments. (A–C) Control unlesioned brain. Intact MBP+ myelin in the corpus callosum. Non-phosphorylated neurofilaments are restricted to the neurons in the cingulate cortex. Ctx: cortex, CC: corpus callosum, LV: lateral ventricle. (D–F) Demyelinated corpus callosum at 7 days post lesioning (dpl) showing a well-defined lesion lacking MBP and upregulated non-phosphorylated neurofilaments. Boundary of the lesion is indicated by arrowheads. (G–I) Demyelinated corpus callosum at 14 dpl showing partial remyelination, characterized by uneven MBP labeling and persistent presence non-phosphorylated neurofilaments. (J–L) Remyelinated corpus callosum at 28 dpl showing uniform MBP labeling and reduced levels of non-phosphorylated neurofilaments, though they are higher than unlesioned corpus callosum. Scale bar: 100 μm.