Table 1. Quantitative-BRET measurements of Gβγ release from different Gα constructs.
NLuc intensity | Basal BRET ratio | ΔBRET ratio | |
---|---|---|---|
M2R-Gαi1(αa-αb) | (13.85 ± 0.36) x105 | 0.301 ± 0.003 | 0.031 ± 0.002 |
β2AR- Gαs(αa-αb) | (11.91 ± 2.80) x105 | 0.310 ± 0.007 | 0.002 ± 0.006 |
M2R-Gαi1(αb-αc) | (8.08 ± 1.77) x105 | 0.310 ± 0.014 | 0.029 ± 0.006 |
β2AR- Gαs(αb-αc) | (8.64 ± 2.62) x105 | 0.311 ± 0.014 | 0.005 ± 0.005 |
D2R-Gαi1(αa-αb) | (23.29 ± 1.46) x105 | 0.312 ± 0.005 | 0.028 ± 0.006 |
β1AR- Gαs(αa-αb) | (24.51 ± 1.09) x105 | 0.315 ± 0.007 | 0.007 ± 0.003 |
D2R-Gαi1(αb-αc) | (5.58 ± 4.31) x105 | 0.287 ± 0.001 | 0.032 ± 0.004 |
β1AR- Gαs(αb-αc) | (7.77 ± 0.34) x105 | 0.279 ± 0.004 | 0.008 ± 0.003 |