FIGURE 5.

Nitric oxide (NO) signaling and known effects on individual transporters involved in transcellular NaCl reabsorption in thick ascending limbs. Arrows indicate stimulation, and T-lines indicate inhibition. Dashed lines indicate that the complete signaling cascade is unknown. AMP, adenosine monophosphate; ClC-K, Cl⁻ channel; CLD19, claudin 19; NHE3, Na⁺/H⁺ exchanger type 3; NKCC2, Na⁺-K⁺-2Cl⁻ cotransporter type 2; NOS3, NO synthase type 3; PDE2, cGMP-stimulated phosphodiesterase; PKA, cAMP-dependent protein kinase; PKG, cGMP-dependent protein kinase; ROMK, renal outer medullary K⁺ channel; sGC, soluble guanylyl cyclase.