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Flow-induced nitric oxide (NO) production via the mechanosensitive transient receptor potential vanilloid type 4 (TRPV4) channel requires the activation of both basolateral P2X and luminal P2Y purinergic receptors. These receptors activate the phosphatidylinositol 3-kinase (PI3K), which in turn phosphorylates protein kinase B (Akt), which phosphorylates NO synthase type 3 (NOS3), increasing NO production.
