FIGURE 16.

Pressure natriuresis relationship in Dahl salt-resistant rats fed normal salt and salt-sensitive rats fed normal and high-salt diets. kw, kidney weight; R/Br, Dahl salt-resistant rats, Brookhaven strain, fed normal salt; S/Br+HS, Dahl salt-sensitive rats, Brookhaven strain, fed high salt; S/Br, Dahl salt-sensitive rats, Brookhaven strain, fed normal salt. Pressure natriuresis was blunted in S/Br by a decrease in slope, while S/Br+HS additionally showed a rightward shift. This indicates that, when hypertension is established after dietary manipulations, renal changes lead to increases in blood pressure that are no longer salt-sensitive. [Adapted from Roman (586).]