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Angiotensin (ANG) II type 2 receptor (AT2R)-mediated nitric oxide (NO) production in Dahl rats. A: the signaling cascade whereby AT2R-mediated NO inhibits Na+-K+-2Cl− cotransporter type 2 (NKCC2) activity in the R phenotype. B: the changes present in the S phenotype leading to a reduced inhibition of NKCC2 by NO. Arrows indicate stimulation, and T-lines indicate inhibition. , superoxide; PDE2, cGMP-stimulated phosphodiesterase; PKG, cGMP-dependent protein kinase.
