FIGURE 23.

Changes in nitric oxide (NO) signaling in thick ascending limbs during angiotensin II (ANG II)-induced hypertension. Black arrows and T-lines indicate normal physiological stimulation and inhibition, respectively. Arrows in red indicate the direction (up: ↑ or down: ↓) of pathological changes occurring during ANG II-induced hypertension. These changes result in altered cGMP levels and reduced inhibition of Na⁺-K⁺-2Cl⁻ cotransporter (NKCC2). NOS3, NO synthase type 3; PDE5, phosphodiesterase 5.