Table 5.
Cell type-specific signal mediators in ANG II-induced vascular structural remodeling
| Cell Type | Mediator | Model | Remodeling | BP | Reference Nos. |
|---|---|---|---|---|---|
| VSMC | ADAM17 | f/f-sm22α Cre | ↓ | ↔ | 1034 |
| VSMC | CaMKII | Inhi* sm22α-Tg | ↓ | ↓ | 836 |
| VSMC | HIF1α | f/f-sm22α Cre | ↓ | ↓ | 414 |
| VSMC | iPLA2β | smmhc-Tg | ↑ | ↑ | 110 |
| VSMC | JAK2 | f/f-sm22α Cre | ↓ | ↓ | 499 |
| VSMC | Nox1 | smmhc-Tg | ↑ | ↑ | 234 |
| VSMC | Sirt1 | sm22α Tg | ↓ | ↓ | 306 |
| Fibroblast | AT1AR | S100A4 Tg | ↓ | ↔ | 825 |
| Macrophage | C1q | C1qa−/− | ↓ | ↔ | 1010 |
| B cell | IgG | BAFF-R−/− | ↓ | ↓ | 134 |
*
Ca2+/calmodulin protein kinase II (CaMKII) peptide inhibitor.