Table 2.
Semi-quantitative specimen-based pathologic diagnosis results (Pathspec, Cellspec, and Necspec), quantitative hotspot pathologic index counting results (Cellcount and Ki-67), and the corresponding APTw and rCBV values for each specimen for all patients
| Case | Specimen No. | Pathspec | Cellspec | Necspec | Cellcount (cells/FOV) | Ki-67 (%) | APTw (%) | rCBV |
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | A | 3 | 1 | 1649 | 47.2 | 3.19 | |
| Q | 1 | 1 | 662 | 17.9 | 1.28 | |||
| 2 | 3 | Q | 1 | 2 | 842 | 2.7 | 1.62 | 1.15 |
| M | 2 | 3 | 876 | 5.1 | 1.81 | 1.68 | ||
| A | 3 | 2 | 1673 | 11.2 | 3.29 | 2.87 | ||
| 3 | 2 | A | 4 | 1 | 1561 | 30.1 | 4.09 | |
| A | 3 | 1 | 1398 | 38.8 | 3.18 | |||
| 4 | 3 | M | 3 | 1 | 658 | 6.5 | 1.82 | 3.74 |
| M | 3 | 1 | 1240 | 4.1 | 2.57 | 3.5 | ||
| M | 3 | 1 | 1036 | 5.2 | 1.33 | 5.02 | ||
| 5 | 3 | M | 2 | 1 | 657 | 10.5 | 3.65 | 0.99 |
| M | 2 | 1 | 615 | 8.4 | 3.77 | 1.38 | ||
| M | 2 | 1 | 748 | 11.9 | 3.64 | 1.08 | ||
| 6 | 5 | Q | 1 | 2 | 541 | 3.2 | 1.20 | 1.36 |
| Q | 2 | 1 | 1188 | 28.6 | 1.39 | 1.68 | ||
| M | 3 | 1 | 1240 | 17.8 | 1.39 | 1.59 | ||
| Q | 2 | 1 | 828 | 20.5 | 1.45 | 1.47 | ||
| M | 1 | 1 | 332 | 9.6 | 1.26 | 1.45 | ||
| 7 | 5 | A | 4 | 1 | 2209 | 4.36 | 2.56 | |
| M | 3 | 2 | 2311 | 47.8 | 2.75 | 1.97 | ||
| M | 3 | 2 | 2403 | 47.1 | 3.90 | 1.65 | ||
| M | 2 | 1 | 2415 | 13.2 | 2.59 | 3.29 | ||
| A | 3 | 1 | 1866 | 49.2 | 3.52 | 3.34 | ||
| 8 | 2 | M | 2 | 3 | 1344 | 2.55 | 2.2 | |
| M | 1 | 2 | 605 | 3.3 | 2.21 | 1.64 | ||
| 9 | 2 | M | 3 | 1 | 1125 | 1.1 | 3.64 | 1 |
| M | 2 | 4 | 1091 | 13.0 | 3.89 | 1.16 | ||
| 10 | 4 | A | 3 | 1 | 1504 | 31.3 | 3.22 | 2.09 |
| M | 3 | 1 | 1168 | 16.1 | 2.42 | 2.05 | ||
| M | 3 | 2 | 2395 | 14.3 | 3.85 | 2.37 | ||
| M | 2 | 1 | 873 | 1.4 | 1.75 | 1.96 | ||
| 11 | 3 | A | 3 | 1 | 1251 | 9.2 | 3.01 | |
| M | 2 | 1 | 983 | 1.1 | 2.84 | |||
| N | 1 | 1 | 237 | 1.30 | ||||
| 12 | 3 | A | 3 | 1 | 1102 | 12.9 | 2.69 | 1.09 |
| A | 2 | 1 | 1116 | 0.4 | 2.38 | 3.39 | ||
| M | 3 | 1 | 1396 | 5.5 | 2.32 | 2.75 | ||
| 13 | 3 | M | 2 | 1 | 343 | 6.1 | 1.05 | 1.29 |
| Q | 2 | 2 | 610 | 8.1 | 0.87 | 1.21 | ||
| Q | 1 | 3 | 457 | 5.7 | 0.88 | 1.03 | ||
| 14 | 2 | A | 4 | 1 | 1287 | 45.4 | 3.42 | 3.02 |
| Q | 2 | 4 | 327 | 2.89 | 1.74 | |||
| 15 | 2 | M | 3 | 1 | 1684 | 16.1 | 2.98 | 2.63 |
| M | 2 | 1 | 1279 | 14.3 | 2.42 | 2.02 | ||
| 16 | 2 | A | 3 | 1 | 1855 | 55.6 | 3.21 | 3.51 |
| A | 3 | 1 | 1408 | 17.1 | 2.98 | 2.55 | ||
| 17 | 4 | Q | 1 | 4 | 702 | 0.7 | 0.99 | 1.13 |
| Q | 2 | 2 | 1619 | 0.9 | 1.26 | 1.67 | ||
| Q | 2 | 1 | 523 | 0.8 | 1.32 | 1.39 | ||
| Q | 2 | 3 | 474 | 4.0 | 0.94 | 1.44 | ||
| 18 | 3 | A | 2 | 1 | 1402 | 0.9 | 1.86 | 1.16 |
| M | 2 | 3 | 925 | 2.2 | 1.04 | 1.1 | ||
| Q | 1 | 4 | 529 | 7.7 | 0.75 | 1.03 | ||
| 19 | 4 | N | 1 | 0 | 372 | 0.0 | 1.21 | 1.09 |
| A | 3 | 0 | 1394 | 33.1 | 3.54 | 1.78 | ||
| M | 2 | 0 | 875 | 10.9 | 3.60 | 1.71 | ||
| M | 2 | 0 | 1248 | 6.1 | 3.25 | 1.64 | ||
| 20 | 3 | N | 1 | 0 | 508 | 3.7 | 1.46 | 1.25 |
| A | 3 | 1 | 907 | 6.8 | 3.51 | 1.69 | ||
| N | 1 | 0 | 652 | 0.6 | 1.70 | 1.4 | ||
| 21 | 4 | A | 2 | 0 | 859 | 14.7 | 3.08 | 1.68 |
| A | 3 | 1 | 1440 | 2.7 | 2.72 | 1.52 | ||
| A | 3 | 1 | 1118 | 2.9 | 2.68 | 1.78 | ||
| A | 4 | 0 | 1389 | 8.1 | 3.05 | 1.72 | ||
Note: Path = histopathologic assignment (A = active; M = mixed; Q = quiescent; N = no tumor), Cell = cellularity (4 = high; 3 = moderate; 2 = low; 1 = very low; or 0 = no tumor); Nec = necrosis (0 = no necrosis; 1 = 1~25%; 2 = 26~50%; 3 = 51~75%; and 4 = 76~100%). Subscript “spec” means the specimen-based measurement from the whole slide. Cellcount and Ki-67 were quantitatively counted by image process software semi-automatically. Notably, three ROIs from Case 13 had consistently lower APTw as well as lower rCBV, but was clinically diagnosed as tumor recurrence.