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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2018 Jul 17;1865(11 Pt B):1698–1706. doi: 10.1016/j.bbamcr.2018.07.004

Figure 2.

Figure 2.

Proteolytic fragments mapped to the Cryo-EM structure of R1. A and C are based on pdb 3JAV. A depicts a single subunit of R1 in which the five tryptic fragments generated by limited trypsin digestion are color coded. B shows these fragments in the linear structure. C Depicts a dimer of R1 in which the soluble (red) and membrane fragments (blue) formed by calpain and caspase activity in vivo are shown. D shows the calpain and caspase fragments in the linear structure of R1.