Table 1:
Major pathways of immunology gene upregulation by bacterial challenge of oral epithelial cells.
| PANTHER Pathways | H. sapiens Genome # | Biofilms # | Expected | Fold Enrichment | Raw P-value | FDR |
|---|---|---|---|---|---|---|
| Biofilm | ||||||
| JAK/STAT signaling pathway | 17 | 6 | .05 | >100 | 6.22E-11 | 2.03E-09 |
| Interferon-gamma signaling pathway | 34 | 6 | .10 | 57.59 | 2.27E-09 | 5.29E-08 |
| Toll receptor signaling pathway | 64 | 11 | .20 | 56.09 | 3.74E-16 | 3.04E-14 |
| B cell activation | 69 | 8 | .21 | 37.84 | 8.66E-11 | 2.35E-09 |
| Interleukin signaling pathway | 94 | 10 | .29 | 34.72 | 7.16E-13 | 2.92E-11 |
| p53 pathway feedback loops 2 | 49 | 3 | .15 | 19.98 | 5.40E-04 | 5.87E-03 |
| VEGF signaling pathway | 68 | 4 | .21 | 19.20 | 6.98E-05 | 8.75E-04 |
| T cell activation | 88 | 5 | .27 | 18.54 | 9.61E-06 | 1.31E-04 |
| PDGF signaling pathway | 142 | 8 | .44 | 18.39 | 1.82E-08 | 3.70E-07 |
| Apoptosis signaling pathway | 129 | 7 | .40 | 17.71 | 1.91E-07 | 2.83E-06 |
| Inflammation mediated by chemokine/cytokine signaling pathway | 286 | 15 | .88 | 17.12 | 1.41E-14 | 7.66E-13 |
| Angiogenesis | 169 | 8 | .52 | 15.45 | 6.60E-08 | 1.19E-06 |
| CCKR signaling map | 180 | 8 | .55 | 14.50 | 1.05E-07 | 1.71E-06 |
| RAS pathway | 76 | 3 | .23 | 12.88 | 1.82E-03 | 1.75E-02 |
| EGF receptor signaling pathway | 153 | 5 | .47 | 10.66 | 1.22E-04 | 1.42E-03 |
| Planktonic | ||||||
| Inflammation mediated by chemokine/cytokine signaling pathway | 286 | 5 | .22 | 23.18 | 1.81E-06 | 2.94E-04 |