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Castration counteracts the hypertensive effect of Ang II, which was restored by testosterone. Intact, castrated and castrated with testosterone replaced rats were infused with Ang II or vehicle for 28 days, as described in Methods. Blood pressures were measured in the experimental groups before and during 28 days of Ang II infusion. Data are expressed as mean ± SEM. *P < 0.05 Ang II vs vehicle, n = 6 for all experiments.
