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. 2019 Jan 10;5:357. doi: 10.3389/fmed.2018.00357

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Copyright © 2019 Lock, Kwok, Kumar, Ahmad-Annuar, Narayanan, Ng, Tan, Kandiah, Tan, Czosnyka, Czosnyka, Pickard and Keong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DTI profiles as radar graphs representing differences across classic NPH, complex NPH, and healthy control cohorts. Due to variations in scanning acquisition between collaborator sites, differences in DTI metrics may not be statistically meaningful. However, DTI profiles provide a methodological tool for comparability across cohorts. As NPH patients displayed worsening functional performance along the disease spectrum (for example, mean MMSE = 24.1 vs. 21.1 for classic vs. complex NPH, respectively), their DTI profiles concurrently worsened to match, across all diffusivity measures. The morphology of DTI profiles also matched the performance of healthy controls (mean MMSE = 28.6 vs. 26.8 for Cambridge vs. Singapore healthy controls).