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. 2019 Jan 10;5:357. doi: 10.3389/fmed.2018.00357

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Copyright © 2019 Lock, Kwok, Kumar, Ahmad-Annuar, Narayanan, Ng, Tan, Kandiah, Tan, Czosnyka, Czosnyka, Pickard and Keong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DTI profiles as line graphs across classic NPH, complex NPH (responder and non-responder), and healthy control cohorts. Differing NPH patient cohorts and healthy controls could be differentiated by the position of their DTI profiles within the spectrum of diffusivity measures. DTI profiles for Cambridge healthy controls^* were the most preserved (highest FA, lowest MD, L1, and L2and3), whereas DTI profiles for complex NPH non-responders^† were the most disrupted (lowest FA, highest MD, L1 and L2and3).