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. 2019 Jan 10;5:357. doi: 10.3389/fmed.2018.00357

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Copyright © 2019 Lock, Kwok, Kumar, Ahmad-Annuar, Narayanan, Ng, Tan, Kandiah, Tan, Czosnyka, Czosnyka, Pickard and Keong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) DTI periventricular white matter tractography model. (Above, left) A typical complex NPH responder demonstrating structural integrity despite white matter disruption. (Below, left) A typical complex NPH non-responder demonstrating severe paucity of tracts and white matter damage. (B) DTI profiles (means with standard error bars) for complex NPH responders, non-responders and classic NPH cohorts. Patterns of directional changes in diffusivity measures for complex NPH responders were consistent with classic NPH, whereas directional changes for non-responders were suggestive of atrophy. MR1 = pre-intervention; MR2 = post-intervention.