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. 2019 Jan 10;12:526. doi: 10.3389/fncel.2018.00526

Figure 5.

Figure 5

Astroglial EVs promote neuronal survival. (A) SH-SY5Y neurons viability in control and oxidative stress (OS) conditions [2 mM paraquat (PQ) for 2 h], measured by the 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay after culture in SM, astrocyte-CM, purified astrocyte EVs, or EV-depleted astrocyte-derived supernatant, Sup. (B) Cell viability of PQ-challenged SH-SY5Y neurons (2 mM PQ for 2 h) in the absence or presence of purified native ApoD and/or an equimolar amount of anti-ApoD antibody. Error bars represent SEM (n = 3 independent experiments with three technical replicas each). Asterisks represent significant differences (p < 0.01) assessed by ANOVA with Holm-Sidak post hoc method. (n.s.: non-significant differences) Only the most relevant comparisons are pointed.