Table 1.

Overview of Similarities and Differences of Calcification in Valves and Vasculature.

Similarities	Differences
Occurs in areas of low and oscillatory shear flow	Presents in different morphology (plaque vs. bone-like nodules)
Specific geometry dictates hemodynamic forces	Clinically different manifestations (atherosclerosis vs. CAVD)
Calcify due in part to endothelial lining disruption	Different interstitial cells maintaining homeostasis