Table 1.

Summary of conserved genes involved in MTOC dynamics/signaling and the correlated genetic diseases.

S. cerevisiae	H. sapiens	Disease	Protein function	Localization yeast/human
CDC5	Plk1	Glioma, several types of carcinoma, melanoma, colorectal cancers, breast cancer, prostate cancer	MTOC separation	SPB outerplaque/centrosome
SFI1	hSFI1	–	MTOC duplication	SPB half bridge/centriole
CDC31	Centrin	–	MTOC duplication	SPB half bridge/centriole
–	hPOC5	Idiopathic scoliosis	Binds Centrin and hSFI1	–
SPC72	Centrosomin CDK5RAP2/Cnn	Autosomal primary recessive microcephaly (MCPH)	MTOC organization	SPB outer plaque/centrosome
–	CEP63, CEP135, CEP152, CPAP/MCPH6, STIL/MCPH7	Autosomal primary recessive microcephaly (MCPH)	Centriole duplication	Centrosome
–	ASPM, WDR62	Autosomal primary recessive microcephaly (MCPH)	Centriole duplication	Spindle poles
SPC110	Pericentrin	Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2)	MTOC maturation	SPB central plaque/centrosome
NUD1	Centriolin	Stem cell myeloproliferative disorder (MPD)	MTOC signaling	SPB outer plaque/centriole
CMD1	Calmodulin	CPV Tachycardia, early-onset severe long QT syndrome (esLQT), idiopathic ventricular fibrillation (IVF)	Calcium binding protein (MTOC structure)	SPB central plaque/nucleus and cytoplasm
TUB4	GCP1	Microcephaly, cortical dysplasia	γ-tubulin	SPB outer and inner plaque/centrosome
SPC97	GCP2	Dilated cardiomyopathy	γ-tubulin small complex	SPB outer and inner plaque/centrosome
SPC98	GCP3	Dilated cardiomyopathy	γ-tubulin small complex	SPB outer and inner plaque/centrosome
CDC15	MST1/2	Breast cancer, soft tissue sarcoma	Signaling kinase (Hippo pathway)	SPB/spindle poles
DBF2/DBF20	LATs/NDR	Breast cancer, astrocytoma	Signaling kinases (Hippo pathway)	SPB/spindle poles
MOB1	MOB1	Colorectal and lung cancers	Co-activator (Hippo pathway)	SPB/spindle poles