Table 2.

Current biopharmaceutical formulations for L-Asparaginase (ASNase).

Approved Biopharmaceuticals	Pharmaceutical form/aspect	Route of administration	Composition	References
ASNase amidohydrolase	Lyophilized white crystalline powder, water soluble (225 IU/mg)	Intravenous/intramuscular	Mannitol (80 mg in 10,000 IU of the enzyme)	Merck, 2000
ASNase from Dickeya chrysanthemi (Erwinia chrysanthemi) (Erwinase®)	Lyophilized white powder, water soluble (10,000 Units)	Intravenous/intramuscular	5 mg glucose per bottle < 1 mmol sodium (23 mg) per dose, i.e., essentially sodium-free	Medicines Evaluation Board, 2015
Recombinant ASNase from Escherichia coli (Spectrila®)	Lyophilized white powder, water soluble (10,000 Units)	Intravenous	Sucrose	European Medicines Agency, 2015
Pegylated ASNase amidohydrolase (Oncaspar®)	Clear, colorless, preservative-free, isotonic sterile solution (3,750 IU/5 mL)	Intravenous/intramuscular	Phosphate buffer (1.20 mg monobasic sodium phosphate, 5.58 mg dibasic sodium phosphate, and 8.50 mg sodium chloride per mL of water for injection)	European Medicines Agency, 2016