Figure 1.

Simplified representation of the neuro-anatomical pathways involved in saccade production. The target information from the frontal eye fields (FEF) diverges into two distinct pathways for generation of motor control signal: The direct pathway, represented as red lines, passes through the superior colliculus (SC) which provides excitatory input drive to the medium lead burst neurons (MLBNs). A displacement integrator (DI) with gain lower than unity is employed to represent the inaccurate feedback information in case of vermal lesions. Additionally, the SC is hypothesized to provide static hold on the eye position by influencing the activity of omnipause neurons (OPNs), represented as dotted lines. The indirect pathway, represented as black lines, undergoes additional processing in the cerebellar oculomotor vermis (OMV), before projecting drive/brake signals to the MLBNs.