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. 2019 Jan 10;12:956. doi: 10.3389/fnins.2018.00956

Figure 7.

Figure 7

PAO inhibition reduced excitotoxicity-induced cell death. (A–D) Representative images showing TUNEL labeling in retinal cryostat sections 3 days following NMDA treatment. The number of cells with fragmented DNA are increased in the WT NMDA retina. PAO inhibition using MDL treatment decreased the number of TUNEL-positive cells in NMDA retinas. Arrows indicate the presence of TUNEL positive cells. (E) Quantitation of TUNEL positive cells showing significantly elevated cell death in NMDA retinas, while MDL treatment reduced excitotoxicity-induced retinal cell death. Data presented as Mean ± SD. *P < 0.01. GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer. Scale bar 100 μm.