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. 2019 Jan 10;12:532. doi: 10.3389/fncel.2018.00532

FIGURE 3.

FIGURE 3

Effect of enriched environment (EE) and the inhibitor of VEGF signaling on spatial and visual memory in high-altitude exposed rats. (A,C,E) Spatial memory tested by the ODT. Shown is total exploration time during training in low altitude and high altitude exposed rats (A) as well as the object displacement discrimination index during test (C,E) in rats housed in standard conditions (SC, white bar) or in enriched environment (EE, patterned bar) (C), as well as in rats in enriched environment receiving either sucrose (EE + veh, black patterned bar) or the inhibitor of VEGF signaling (EE + inh, red patterned bar) (E). (B,D,F) Visual memory tested by the ORT. Shown is total exploration time during training in low altitude and high altitude exposed rats (B) as well as the object replacement discrimination index during test (D,F) in rats housed in standard conditions (SC, white bar) or in enriched environment (EE, patterned bar) (D), and in rats housed in enriched environment receiving sucrose (EE + veh, patterned bar) or in enriched environment receiving the inhibitor of VEGF signaling (EE + inh, red patterned bar) (F). Statistics 2-way ANOVA (∗∗∗∗P < 0.0001, ∗∗∗P < 0.001, ∗∗P < 0.01, P < 0.05) with n = 12; error bars indicate SD.