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. 2019 Jan 16;9(2):7. doi: 10.1038/s41408-019-0170-3

Fig. 3. Karyotype and VAF of driver mutations in primary tumor (n = 10), remission (n = 6) and relapse (n = 10) tumors.

Fig. 3

a The mutations detected in the primary and relapse tumor samples from eight patients (UPN1,5,6,7,9,10,12 and 14) with AML: the founding clone in the primary tumor gained relapse-specific mutations or cytogenetic abnormalities and evolved into a relapse clone. b The mutations detected in the primary and relapse tumor samples from two patients (UPN3 and 15) with AML: the founding clone detected at relapse was different from the founding clone at diagnosis (the relationship between mutations in the primary and relapse tumors are shown by lines linking them). Remisison bone marrow samples were available only for six patients VAF: variant allele frequency ¥UPN5: *p.R1537X, †p.I1116fs µUPN3: *p.G289fs, †p.K413fs