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. 2019 Jan 16;10:254. doi: 10.1038/s41467-018-08109-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Proteomic profiling of proteins bound to circulating immunoglobulins. a Schematic of the work-flow used for the proteomic analysis of Ig-bound proteins in the plasma of PDAC cancer patients. b Schematic of PDAC cohorts, which underwent MS analysis of Ig-bound proteins. In cohort #1, pools of potentially resectable or locally advanced PDAC patient plasma were compared to pools of benign pancreatic cyst patient samples, matched based on type 2 diabetes (T2D) status. In cohort #2, pools of stage I or stage II PDAC patient plasma were compared to pools of matched healthy subject or chronic pancreatitis patient samples. (c) GO MetaCore localization analysis of the proteins identified at higher levels in the Ig-bound fraction of cancer cases compared to matched controls in the PDAC cohorts. The number of genes in the input list belonging to each specific localization is listed. Arrows indicate exosome, vesicle, and endosome localizations