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Effects of CRE and CSE on mRNA expression of genes involved in melanogenesis. Total RNA from B16F10 cells treated with CRE and CSE extracts were collected at 48 h, and levels of (A) MITF (B) TYR (C) TRP-1 (D) TRP-2 mRNA were determined by qPCR, using GAPDH as an internal control. ##P < .01, ###P < .001: statistically significant vs control group and *P < .05, *P < .01, ***P < .001 vs α -MSH group.
