Figure 2.

Interactions among mechanisms in illness progression and high-risk behaviour: (1) immediate, including stress-related arousal; (2) short-term, including expression of sensitized behaviour; and (3) long-term, including exposure to potentially sensitizing stimuli. Bipolar disorder is enriched in each risk category. Each risk category can interact with the other categories and can contribute to risk in its own right. MSSA, medically severe suicide attempt.