Table 3.
Cost and affordability of average 30‐day supply of available medications for treatment of PD in Nigeria
| Medication | Originator or Generic | Dosage Strength (mg) | Presumed Monthly Need | Price per Tablet (N) (Mean ± SD) | Cost per 30‐Day Supply (N/US$)* | No. of Day's Wages for 30‐Day Supply† | Affordability (30‐Day Cost > N600)‡ |
|---|---|---|---|---|---|---|---|
| l‐dopa/carbidopa 250/25 | Originator | 250/25 | 90 tablets | 173.7 ± 69.8 | 15,633 (43.4) | 26 | No |
| l‐dopa benserazide 250/25 | Originator | 250/25 | 90 tablets | 139.4 ± 51.0 | 12,546 (34.9) | 21 | No |
| l‐dopa/carbidopa CR 100/25 | Originator | 100/25 | 90 tablets | 181.3 ± 14.0 | 16,320 (45.3) | 27 | No |
| l‐dopa/carbidopa CR 200/50 | Originator | 200/50 | 60 tablets | 163.5 | 9,810 (27.2) | 16 | No |
| l‐dopa/carbidopa/entacapone | Originator | 100/25/200 | 90 tablets | 877.0 | 78,930 (219.2) | 132 | No |
| Bromocriptine | Generic | 2.5 | 90 tablets | 83.4 ± 14.1 | 7,506 (20.9) | 12.5 | No |
| Bromocriptine | Originator | 2.5 | 90 tablets | 124.6 ± 37.4 | 11,214 (31.2) | 19 | No |
| Pramipexole | Originator | 0.18 | 90 tablets | 176.9 ± 8.1 | 15,921 (44.2) | 26 | No |
| Ropinirole | Originator | 2 | 60 tablets | 113.2 | 6,794 (18.9) | 11 | No |
| Ropinirole XL 2 mg | Originator | 2 | 60 tablets | 481.4 | 28,886 (80.2) | 48 | No |
| Rotigotine | Originator | 1 | 30 patches | 7,416 | 222,500 (618) | 371 | No |
| Selegiline | Generic | 5 | 60 tablets | 100 ± 8 | 6,000 (16.7) | 10 | No |
| Rasagiline | Originator | 5 | 30 tablets | 145.7 ± 19.6 | 8,742 (24.3) | 15 | No |
| Entacapone | Originator | 200 | 90 tablets | 122.7 ± 85.8 | 11,043 (30.7) | 18 | No |
| Trihexyphenidyl | Generic | 5 | 90 tablets | 8.2 ± 9.1 | 738 (2.1) | 1 | Yes |
| Trihexyphenidyl | Originator | 5 | 90 tablets | 40.4 ± 48.5 | 3,636 (10.1) | 6 | No |
| Biperiden (injection) | Originator | 5 mg/1 mL | 1 vial | 788.3 ± 462.0 | 788 (2.2) | 1 | Yes |
| Amantadine | Generic | 100 | 90 tablets | 445.3 ± 376.1 | 40,077 (111.3) | 67 | No |
| Amantadine | Originator | 100 | 90 tablets | 1,091.1 | 98,199 (272) | 164 | No |
| Clozapine | Generic | 100 | 30 tablets | 132.5 ± 17.5 | 3,975 (11.0) | 7 | No |
| Clozapine | Originator | 100 | 30 tablets | 211.5 ± 109.8 | 6,345 (17.6) | 11 | No |
| Quetiapine | Generic | 100 | 30 tablets | 40.4 ± 4.3 | 1,212 (3.4) | 2 | No |
| Quetiapine | Originator | 100 | 30 tablets | 307.5 ± 42.5 | 9,225 (25.6) | 15 | No |
| Nortryptilline | Generic | 25 | 60 tablets | 254.8 ± 239.1 | 15,288 (42.5) | 26 | No |
| Memantine | Originator | 10 mg | 60 tablets | 546.4 ± 484.4 | 32,784 (91.1) | 54.6 | No |
| Rivastigmine | Originator | 1.5 | 60 tablets | 759.5 ± 527.8 | 45,570 (126.6) | 76 | No |
| Donepezil | Generic | 5 mg | 30 tablets | 87.3 ± 69.9 | 2,619 (7.3) | 4 | No |
| Donepezil | Originator | 5 mg | 30 tablets | 216.1 ± 22.7 | 6,483 (18.0) | 11 | No |
| Fludrocortisone | Originator | 0.1 mg | 60 tablets | 411.0 | 24,660 (68.5) | 41 | No |
| Oxybutinin | Generic | 2.5 | 60 tablets | 75.1 ± 90.8 | 4,506 (12.5) | 7.5 | No |
| Melatonin | Generic | 3 mg | 30 tablets | 50.8 ± 47.4 | 1,524 (4.2) | 2.5 | No |
| Imipramine | Originator | 25 mg | 30 tablets | 37.5 | 1,125 (3.1) | 2 | No |
| Aripiprazole | Originator | 10 mg | 30 tablets | 2,250 | 67,500 (187.5) | 112 | No |
Footnote: N = Nigerian Naira; US$ = U.S. dollar.
*
30‐day cost calculated as price per tablet × presumed monthly need.
†
Calculated based on 30‐day cost/daily minimum wage of N600.
‡
Affordability based on cost of monthly supply not exceeding 1 day's minimum wage (N600); average number of day's minimum wages to purchase 30‐day supply = 41.