Table 1.

Percent GC content and nucleotide identity between posited chromosomal donors and the corresponding mobilized resistance genes for a number of antibiotics.

	Putative donor	%GC	Mobile determinant	%GC	% Identity	PMID
Sulfonamide	Leptospira interrogans	32.62	Salmonella enterica sul3 (WP_117344859.1)	37.75	51.91	(This work)
	Leptospiraceae	39.39 ± 4.17	sul3 group	38.14 ± 0.55	49.73 ± 1.55	(This work)
	Spirochaetales	52.22 ± 9.24	sul3 group	38.14 ± 0.55	47.28 ± 2.63	(This work)
	Parvibaculum lavamentivorans	64.48	Pasteurella multocida sul2 (WP_010890206.1)	60.61	63.33	(This work)
	Rhodobiaceae	62.02 ± 2.22	sul2 group	59.6 ± 2.70	60.46 ± 2.37	(This work)
	Alphaproteobacteria	62.34 ± 13.20	sul2 group	59.6 ± 2.70	48.14 ± 3.28	(This work)
	Parvibaculum lavamentivorans	64.48	Acinetobacter baumannii sul1 (AFB76381.1)	61.78	54.65	(This work)
	Rhodobiaceae	62.02 ± 2.22	sul1 group	61.72 ± 0.09	54.06 ± 0.51	(This work)
	Alphaproteobacteria	62.34 ± 13.20	sul1 group	61.72 ± 0.10	46.50 ± 3.48	(This work)
Vancomycin	Amycolatopsis orientalis	64.86	vanX	64.59	76.57	22303296
Quinolones	Shewanella algae	53.12	qnrA	53.27	95.6	16048974
	Vibrio splendidus	44.44	qnrS	43.99	72.78	17452482
β-lactams	Kluyvera cryocrescens	54.02	CTX-M-1	54.11	99.3	11709346
	Kluyvera ascorbata	56.62	CTX-M-2	56.73	99.2	12183268
	Kluyvera georgiana	57.07	CTX-M-8	57.08	98.5	12435721
	Kluyvera georgiana	57.64	CTX-M-9	60.5	99	15855541
	Kluyvera georgiana	57.53	CTX-M-25	57.99	95.9	20421403

Groups of homologs for sul genes correspond to sequences with at most 90% similarity to reported sul genes. For each donor clade and target group, the most likely mapping is shown. Where appropriate, the PudMed identifier (PMID) for the reference establishing the correspondence between putative chromosomal donor and mobile resistance determinant is provided.