Figure 2.

Contraction and Relaxation Kinetics Are Altered by HCM Mutations

(A) Representative twitch force tracings from MYH7-R403Q^+/– CMT models compared with isogenic controls.

(B–D) Normalized maximum contraction velocity (B), contraction time (C), and relaxation half-time (t_1/2) (D) for MYBPC3^+/−, MYBPC3-R502W^+/–, and MYH7-R403Q^+/– compared with controls.

Significance was assessed by ANOVA (B–D) (^∗all p < 0.05 and ^∗∗all p < 0.001); data are means ± SEM (error bars) (A–D). Each data point represents a single CMT (B–D) generated by at least three biological replicates by iPSC differentiation batch.