Contraction and Relaxation Kinetics Are Altered by HCM Mutations
(A) Representative twitch force tracings from MYH7-R403Q+/– CMT models compared with isogenic controls.
(B–D) Normalized maximum contraction velocity (B), contraction time (C), and relaxation half-time (t1/2) (D) for MYBPC3+/−, MYBPC3-R502W+/–, and MYH7-R403Q+/– compared with controls.
Significance was assessed by ANOVA (B–D) (∗all p < 0.05 and ∗∗all p < 0.001); data are means ± SEM (error bars) (A–D). Each data point represents a single CMT (B–D) generated by at least three biological replicates by iPSC differentiation batch.