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. 2019 Jan 12;11:85–97. doi: 10.1016/j.dadm.2018.11.003

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Serum levels of proteins associated with Aβ clearance and cholesterols associated with reduced rCBF and atrophy of the medial temporal structures. (A) Serum levels of apoA-I and HDL were correlated with the medial temporal structure volume, including the entire region of the entorhinal cortex, hippocampus, and amygdala, as detected by VSRAD. MRI data were analyzed visually and by voxel-based morphometry techniques to detect regional volume changes. (B) Changes in apoA-I, aC3, nC3, aC3/nC3, TTR, triple-marker, HDL, and TC levels with reduction of rCBF were evaluated by SPECT. Abbreviations: aC3, active form of C3; nC3, native form of C3; TC, total cholesterol; TTR, transthyretin; rCBF, reduced cerebral blood flow; VSRAD, voxel-based specific regional analysis system for Alzheimer's disease; SPECT, single-photon emission tomography.

Fig. 2 — Serum levels of proteins associated with Aβ clearance and cholesterols associated with reduced rCBF and atrophy of the medial temporal structures. (A) Serum levels of apoA-I and HDL were correlated with the medial temporal structure volume, including the entire region of the entorhinal cortex, hippocampus, and amygdala, as detected by VSRAD. MRI data were analyzed visually and by voxel-based morphometry techniques to detect regional volume changes. (B) Changes in apoA-I, aC3, nC3, aC3/nC3, TTR, triple-marker, HDL, and TC levels with reduction of rCBF were evaluated by SPECT. Abbreviations: aC3, active form of C3; nC3, native form of C3; TC, total cholesterol; TTR, transthyretin; rCBF, reduced cerebral blood flow; VSRAD, voxel-based specific regional analysis system for Alzheimer's disease; SPECT, single-photon emission tomography.