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. 2018 Dec 27;12(1):6–13. doi: 10.1016/j.stemcr.2018.11.022

Figure 4.

Figure 4

CXCR4/SDF1 Signaling Is Dysregulated in the Aging V-SVZ

(A) Numbers of EdU-positive cells in V-SVZ whole mounts in 2-month-old and 12-month-old mice (n = 4; ∗∗p < 0.01 by Student's t test).

(B) qRT-PCR analysis of Cxcr4 and Sdf1 expression in the V-SVZ of young and aged mice (n = 4/group).

(C) Representative confocal images of CXCR4 immunohistochemistry in coronal sections of the V-SVZ in 2-month-old and 12-month-old mice. Scale bars, 50 μm.

(D) Distribution of proliferating cells relative to Sdf1DsRed-positive vasculature. n = 5,793 cells for young mice, n = 2,208 cells for aged mice measured in 4 mice (∗∗∗∗p < 0.001 by Mann-Whitney test).