Figure 6.

Ripple-associated MD modulation varies across behavioral states. A, Bidirectional changes of MD MUA around ripples. Example raster plots (top) and corresponding averages of z-scored MD firing rates (bottom) are plotted around 100 randomly selected ripples. B, Distribution of b-MIs generated by bootstrapping ripples during awake state (black) and NREM sleep (white). The vertical dashed lines mark the lower and upper limits of 95% confidence interval. Note that all b-MIs during awake state are negative, indicating consistent MD suppression, while both negative and positive b-MIs were obtained during NREM sleep.