Table 2.
Results of the association study in the initial UK Biobank sample (UKB1), the UKB2 sample, and a meta-analysis of the two studies
| Gene | SNP | CHR:BP | EFF/ALT | UKB1 (N ~ 110 000) | UKB2 (N ~ 255 000) | META | |||
|---|---|---|---|---|---|---|---|---|---|
| Beta (SE) in minutes | P-value | Beta (SE) in minutes | P-value | Beta (SE) in minutes | P-value | ||||
| DAT1 | rs40184 | 5:1,395,077 | T/C | 0.12 (0.30) | 0.603 | 0.24 (0.18) | 0.137 | 0.24 (0.18) | 0.126 |
| rs11133767 | 5:1,401,580 | T/C | 0.36 (0.30) | 0.239 | 0.48 (0.18) | 0.015 | 0.42 (0.18) | 7.30 × 10−3 | |
| rs464049 | 5:1,423,905 | G/A | −1.20 (0.30) | 1.72 × 10−5 | −0.84 (0.18) | 4.24 × 10−7 | −0.96 (0.18) | 5.71 × 10−10 | |
| rs460000 | 5:1,432,825 | T/G | −1.20 (0.36) | 5.44 × 10−4 | −0.72 (0.24) | 1.59 × 10−3 | −0.84 (0.18) | 5.77 × 10−6 | |
| DRD2 | rs11214607 | 11:113,312,139 | G/T | 0.84 (0.36) | 0.025 | 1.08 (0.24) | 1.73 × 10−5 | 1.02 (0.18) | 1.39 × 10−6 |
| rs17601612 | 11:113,317,745 | C/G | −0.90 (0.30) | 1.23 × 10−3 | −0.54 (0.18) | 2.56 × 10−3 | −0.66 (0.18) | 1.77 × 10−5 | |
CHR = chromosome; BP = base pair position in hg19; EFF = effect allele; ALT = alternate allele. Linear regression analysis in PLINK in the primary population of 111 975 and the secondary population of 261 870 people, and a meta-analysis of both the initial and follow-up studies done in METAL. Beta and standard error are in minutes.